hrp0086p1-p10 | Adrenal P1 | ESPE2016

Current Dilution Methods Cause Large Variations and Inaccuracies when Making up 1 μg Synacthen Dose

Cross Alexandra S , Sachdev Pooja , Wright Neil P , Jabbar Imran , Elder Charlotte J

Background: The low-dose short Synacthen test is a popular diagnostic test of adrenal insufficiency in children. It is employed by 82% of UK paediatric endocrinologists. Although various dosing strategies exist, 1 μg is most commonly employed, however none of the low-dose forms are commercially available. A BSPED survey revealed 14 different methods for diluting 250 μg/ml ampoules.Objective and hypotheses: Do various dilution strategies result ...